Choosing the Most Effective Antibiotics for Eye Infections

The purpose of the treatment of ocular infections caused by bacteria is to achieve high levels of antibiotics that could be maintained at the infection site so that the bacterial eradication can occur more quickly.
 
 
From the World Ophthalmology Congress (WOC) 2008 in Hong Kong, a panel of experts from various institutions presented the quite interesting theme; the selection of appropriate antibiotics to prevent and cope with various types of eye infections. In one of the symposiums, the topic was led by Professor Yasuo Tano from Osaka University Medical School, Osaka, Japan. The focus of the symposium was the latest generation of topical antibiotic from the fluoroquinolone class, namely efficacy and safety of levofloxacin 0.5% in the management of conjunctivitis and keratitis bacterial.

The purpose of the treatment of ocular infections caused by bacteria is to achieve high levels of antibiotics that could be maintained at the infection site so that the bacterial eradication can occur more quickly. Compared with the previous-generation of topical fluoroquinolone, levofloxacin could reach the highest concentrations and can be maintained in the tissue of tears and eyes.

Concentration and penetration of the drug into the eye tissue is as important as low drug resistance factors. Those three things are major factors in the effective treatment of eye infections. The high concentration and ocular penetration of the new generation of topical fluoroquinolone, such as levofloxacin 0.5%, would make the eradication of bacteria more effective and reduce the risk of resistance.

The selection of antibiotics for ocular infections is ideally based on the identification of the specific bacteria. In addition, the effect of the antibiotics on the conditions and the migration of the cornea should also be taken into consideration, especially in the case of the cornea damage. (Source: Ophthalmology Update, October 2008 Edition | Page 1-4)

The complete article (in Bahasa) can be downloaded from the files below.

 

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